Self-immolative dendrimers as novel drug delivery platforms
نویسندگان
چکیده
منابع مشابه
Dendrimers: Nanopharmaceuticals for Drug Delivery
Dendrimers are new class of polymeric materials. It is generally described as a macromolecule, which is characterized by its extensively branched 3D structure that provides a high degree of surface functionality and versatility. Dendrimers are highly branched, globular macromolecules with many arms emanating from a central core. The unique properties associated with these dendrimers such as uni...
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Dendrimers are a novel class of structurally controlled macromolecules which have the structure like a tree or star shape, with a central core, interior branches and terminal groups decorate the surface and from the cavity inside the core. Dendrimers have well defined size, shape, molecular weight and monodispersity and reactivity are determined by generation (shells) and chemical composition o...
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The investigation of synthetic polymers for biological applications is increasing as assembly techniques for generating welldefined macromolecules from artificial building blocks become more sophisticated. Synthesis techniques have now evolved such that a wide variety of functional groups can be tolerated by polymerization catalysts, and a fascinating and diverse range of macromolecular and pol...
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Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Meth...
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Polycations are explored as carriers to deliver therapeutic nucleic acids. Polycations are conventionally pharmacological inert with the sole function of delivering therapeutic cargo. This study reports synthesis of a self-immolative polycation (DSS-BEN) based on a polyamine analogue drug N(1),N(11)-bisethylnorspermine (BENSpm). The polycation was designed to function dually as a gene delivery ...
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ژورنال
عنوان ژورنال: Journal of Polymer Science Part A: Polymer Chemistry
سال: 2006
ISSN: 0887-624X
DOI: 10.1002/pola.21258